General Information

  • ID:  hor003217
  • Uniprot ID:  NA
  • Protein name:  Endomorphin
  • Gene name:  NA
  • Organism:  NA
  • Family:  Opioid neuropeptide precursor family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  YPW/FF
  • Length:  6
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T4 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003217_AF2.pdbhor003217_ESM.pdb

Physical Information

Mass: 83021 Formula: C43H44N6O6
Absent amino acids: ACDEGHIKLMNQRSTV Common amino acids: F
pI: 6.09 Basic residues: 0
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: 30 Boman Index: 815
Half-Life / Aliphatic Index: 2.8 hour Aliphatic Index: 0
Instability Index: 2076.67 Extinction Coefficient cystines: 6990
Absorbance 280nm: 1398

Literature

  • PubMed ID:  17276550
  • Title:  In Vitro and in Vivo Characterization of opioid neuropeptide precursor family Activities of Endomorphins Analogs With Novel Constrained C-terminus: Evidence for the Important Role of Proper Spatial Disposition of the Third Aromatic Ring