HORDB

General Information

ID: hor003217
Uniprot ID: NA
Protein name: Endomorphin
Gene name: NA
Organism: NA
Family: Opioid neuropeptide precursor family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: NA
GO MF: NA
GO BP: NA
GO CC: NA

Sequence Information

Sequence: YPW/FF
Length: 6
Propeptide: NA
Signal peptide: NA
Modification: T4 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Activity

Function: NA
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003217_AF2.pdb

hor003217_ESM.pdb

Physical Information

Mass:	83021	Formula:	C43H44N6O6
Absent amino acids:	ACDEGHIKLMNQRSTV	Common amino acids:	F
pI:	6.09	Basic residues:	0
Polar residues:	1	Hydrophobic residues:	3
Hydrophobicity:	30	Boman Index:	815
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	0
Instability Index:	2076.67	Extinction Coefficient cystines:	6990
Absorbance 280nm:	1398

Literature

PubMed ID: 17276550
Title: In Vitro and in Vivo Characterization of opioid neuropeptide precursor family Activities of Endomorphins Analogs With Novel Constrained C-terminus: Evidence for the Important Role of Proper Spatial Disposition of the Third Aromatic Ring